Fabrication, Crosslinking, and Characterization of PGS-based fiber mats for cardiac tissue engineering

 

Investigator: Abdelmalek Eladlani (Bachelor student) Abdelmalek Eladlani

 

Supervisor: Lena Vogt, Prof. Dr.-Ing. habil. Aldo R. Boccaccini


Poly(glycol sebacate) (PGS) is a biopolymer increasingly used in biomedical applications, especially in connection with soft tissue engineering [1]. This project focuses on the optimization of PGS-based fiber mats, intended for use as cardiac patches. PGS will be blended with natural biopolymers to improves the biological compatibility [2]. A particular importance is attached to the crosslinking of the natural components in the blends in order to enhance mechanical properties and water stability. The fabricated fiber mats will be investigated regarding their morphological, chemical, mechanical and degradation properties.

[1] Rai, Ranjana, et al. Synthesis, properties and biomedical applications of poly(glycerol sebacate) (PGS): a review. Progress in Polymer Science 37 (2012) 1051-1078.

[2] Vogt, Lena, et al. Electrospun zein fibers incorporating poly(glycerol sebacate) for soft tissue engineering. Nanomaterials 8 (2018) 150.