Interaction of proteins with bioreactive surfaces

 

Investigator: Dr.-Ing. Mirza Mačković (Post Doc)Mirza Mačković

Cauerstraße 6
91058 Erlangen

room 0.211

phone: +49 (0)9131 85-20807

email: mirza.mackovic@ww.uni-erlangen.de

 

Supervisor: Prof. Dr.-Ing. habil. Aldo R. Boccaccini

The adsorption of serum proteins on foreign solids leads to the formation of a protein layer (also known as biomolecular corona), which determines the biological identity of the material and is of key importance for the function of its surface [1]. It is well-known that the formed protein layer significantly affects the physicochemical activities (e.g., formation of hydroxyapatite) and controls the biological behaviour (e.g., attachment, proliferation and migration of cells) of biomaterials [2,3]. Hence, the understanding and control of interactions between proteins and biomaterials is of crucial importance for any progress in biomedical applications and/or design of advanced biomedical devices. The current project is focused on the interaction of bioreactive surfaces with proteins. The main work comprises a comprehensive composition- and size-dependent material synthesis and multidisciplinary investigations of protein-surface interactions.

[1] Gray JJ., Curent Opinion in Structural Biology 2004; 14: 110–115.

[2] Wang K, et al., Interface Focus 2012; 2: 259–277.

[3] Wei Q, et al., Angewandte Chemie – International Edition 2014; 53: 8004–8031.