Fabrication and characterization of gelatin nanoparticulate drug vehicles for coatings on metallic substrates

 

Investigator: Svenja Heer (Bachelor student) 

Svenja Heer

 

Supervisors: Svenja Heise, Prof. Aldo R. Boccaccini


This project is principally concerned with the fabrication and characterization of drug delivery coatings on stainless steel based on a biopolymer matrix and gelatin nanoparticles in order to obtain an antibacterial coating on orthopedic implants. At first nanoparticulate drug vehicles will be produced. After that they will be integrated in the biopolymer matrix and electrophoretic deposition (EPD) will be used to coat the stainless steel substrate with the drug loaded vehicles following previous studies in our Institute [1, 2]. The resulting coating will be characterized in terms of coating adhesion, wettability and drug release capability. The project is carried out in collaboration with the School of Life Sciences in Northwestern Polytechnical University, China.

[1] Song, J., et al., Electrophoretic Deposition of Chitosan Coatings Modified with Gelatin Nanospheres To Tune the Release of Antibiotics, ACS Appl. Mater. Interfaces 8 (2016) 13785-13792.

[2] Chen, Q., et al., Electrophoretic deposition of antibiotic loaded PHBV microsphere-alginate composite coating with controlled delivery potential, Colloids and Surfaces B: Biointerfaces 130 (2015) 199–206.