45S5 Bioglass-based scaffolds coated with mesoporous nanoparticles incorporated with phytotherapeutics for bone tissue engineering

 

Investigator: Varun Tharmalingam (Bachelor student) Varun Tharmalingam

 

Supervisors: Qaisar Nawaz, Prof. Dr.-Ing. habil. Aldo R. Boccaccini


In this Bachelor thesis research project, a variety of plant extracts are incorporated into mesoporous bioactive glass nanoparticles [1] which will be further used to coat standard 45S5 bioactive glass-based scaffolds fabricated by the foam replica method [2]. The new scaffolds will be characterized in terms of morphology, in-vitro bioactivity, phytotherapeutic agent release capability and cytocompatibility. The successful completion of the project will provide a new path towards novel functionalized bioactive glass scaffolds for bone tissue engineering.

[1] Galarraga-Vinueza ME, et al., Anti-biofilm properties of bioactive glasses embedding organic active compounds. J Biomed Mater Res Part A 2017:105A:672–679.

[2] Chen QZ, et al., 45S5 Bioglass®-derived glass–ceramic scaffolds for bone tissue engineering. Biomaterials 2006:27: 2414-2425.